Sleepy Fools
Regarding if we should avoid disagreeing, Eliezer once wrote:
The central argument for Modesty proposes something like a Rawlsian veil of ignorance - how can you know which of you is the honest truthseeker, and which the stubborn self-deceiver? ... the obvious reply: "But I know perfectly well who the fool is. It's the other guy. It doesn't matter that he says the same thing - he's still the fool." This reply sounds bald and unconvincing when you consider it abstractly. But if you actually face a creationist, then it certainly feels like the correct answer. ...
Those who dream do not know they dream; but when you wake you know you are awake. Dreaming, you may think you are awake. You may even be convinced of it. But right now, when you really are awake, there isn't any doubt in your mind - nor should there be. ... [you have] just an (ahem) incommunicable insight that you were awake. ... "That we can postulate a mind of sufficiently low (dreaming) or distorted (insane) consciousness as to genuinely not know whether it's Russell or Napoleon doesn't mean ... [I'm] Napoleon.
Are sleepers who think they are awake a good analogy for justified disagreement with fools? Do sleepers and fools both have a broken mental state blocking them from assimilating key relevant info? Interestingly, the merely sleepy do seem to know they are sleepy:
Sixty-four adults participated in a study examining the accuracy of metacognitive judgments. During 28 hr of sleep deprivation (SD) and continuous cognitive work. ... Subjective and objective measures of sleepiness confirmed the expected patterns of increasing fatigue with SD. ... Traditional indices of the confidence-accuracy relation (i.e., calibration, resolution, over- and underconfidence), as well as the accuracy of pre- and posttask estimates of performance, remained stable over the SD period. The findings suggest that people can accurately assess their own cognitive performance when deprived of 1 night of sleep.
Apparently it is also possible to know that you are dreaming:

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